Celiac Disease Comprehensive Antibody Profile
Preparation: No special preparation is needed. Fasting is not required for this blood test. In general, being well hydrated (drinking plenty of water before the blood draw) will help make your veins somewhat easier to locate and access for the blood draw.
Estimated time to receive results is up to 14 days.
CPT Code(s) 83516, 82784 Quest test code 19955
Includes: Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.
If the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed (CPT code(s): 86256).
If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed (CPT code(s): 83516).
Methodology: Immunoassay (IA) • Immunoturbidimetric Assay
Please be advised, that our services are strictly self pay and are not eligible for submission as a claim to your health insurance provider. However, you can submit the receipt for reimbursement to many Flexible Spending and Health Savings Accounts for reimbursement.