Celiac Disease Comprehensive Antibody Profile

 Preparation: No special preparation is needed. Fasting is not required for this blood test. In general, being well hydrated (drinking plenty of water before the blood draw) will help make your veins somewhat easier to locate and access for the blood draw.

Estimated time to receive results is up to 14 days.

CPT Code(s) 83516, 82784  Quest test code 19955

Includes: Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

Clinical Significance:
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

Reflex Information:
If the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed (CPT code(s): 86256).
If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed (CPT code(s): 83516).

Methodology: Immunoassay (IA) • Immunoturbidimetric Assay

Please be advised, that our services are strictly self pay and are not eligible for submission as a claim to your health insurance provider. However, you can submit the receipt for reimbursement to many Flexible Spending and Health Savings Accounts for reimbursement.

 Sample of Celiac Disease Comprehensive Antibody Profile test

For more Information on any of your lab test results:

  • Consult your physician
  • Review the information on the independent, non-profit web site: www.labtestsonline.org

These are not intended as diagnostic comments, but only to give you sufficient information for further discussion with your physician. It is important that you promptly consult your physician regarding any abnormal findings.

 

 Preparation: No special preparation is needed. Fasting is not required for this blood test. In general, being well hydrated (drinking plenty of water before the blood draw) will help make your veins somewhat easier to locate and access for the blood draw.

Estimated time to receive results is 3-4 business days.

CPT Code(s) 83516, 82784  Quest test code 19955

Includes: Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

Clinical Significance:
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

Reflex Information:
If the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed (CPT code(s): 86256).
If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed (CPT code(s): 83516).

Methodology: Immunoassay (IA) • Immunoturbidimetric Assay

 Sample of Celiac Disease Comprehensive Antibody Profile test

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